As an academic periodical printed in mainland China during the years of 1927- 1952, and with most of its papers published in English, the Chinese Journal of Physiology holds a significant position in the history of development of modern life sciences in China. After a brief introduction to its publication cycles and the compliments it has received, this paper evaluates the journal＇s instant and long-term impacts in the international scientific community on the base of citation counts found in the Science Citation Index by the year 2010. Calculations show that the average impact factor of the journal is at least 0. 22± 0. 05, a higher figure compared to that of its successor, Acta Physiologica Sinica. Citation counts till 2010 suggest that the journal enjoys a lasting favorable reputation, though its publication cycles and cited times were often greatly interfered by social and political turbulences. By April 2010, 56 articles, which amount to 7.8% of all the items ever published in the journal, won it 50% of its total citation times. Analysis of the 56 most frequently cited articles reveals： 1 ） These articles can be grouped into a dozen pieces of research work; 2 ） The works were generally done at the Peking Union Medical College and Hospital; 3 ） The works were almost all engaged in elucidating general principles of life, rather than developing a research line from specific native resources. In a word, the Chinese Journal of Physiology reflects an intrinsic paradigm of physiological research, and highlights as well the value of its achievements.